Chemical Analysis of Skin Fillers

During the natural aging process of human skin, subcutaneous fat tissue and dermal support tissue decrease, the skin becomes thinner and loses its elasticity. Disorders appear in the facial appearance, cheeks and lips begin to lose their fullness, deep wrinkles appear, nasolabial folds become evident and other undesirable skin defects begin to appear.

Today, many methods have been developed in facial aesthetics to look younger and more flawless. Among these methods, dermal filler injections constitute an acceptable alternative for people who are hesitant about plastic surgery operations. In some cases, dermal fillers are applied to delay surgical operations or as an additional treatment to surgery.

Filler injections are the process of placing various fillers into the dermis. The injected filler creates volume in the dermis, eliminating lines and wrinkles. This method is an ideal treatment for static wrinkles on the skin. These substances are used not only to eliminate wrinkles, but also to correct some dermal depressions, traumatic skin scars and facial contours, and to keep the skin moist.

There are some important factors that affect the cosmetic result of the skin filling procedure. These factors include choosing the right product according to the localization to be injected, the injection technique used, appropriate patient selection and expectations of the patient, the experience of the doctor, and procedures such as botulinum toxin injection and chemical peeling applied together.

In choosing the appropriate filler, it is necessary to carefully evaluate the particle sizes, concentration, permanence, side effects and late complications of the filler used. It is considered appropriate to inject products with small particles into the superficial dermis in the treatment of fine lines such as lines around the eyes and mouth, and products with large particles into the middle dermis in the treatment of deeper lines such as nasolabial lines. It is important to choose the appropriate product according to the area to be applied. The properties of the skin, vascular structure, thickness, tension, mechanical movements, tissue surface, and depth of the line or wrinkle are important in this operation. High viscosity products with thick needles are a suitable choice for large scars. To correct fine, superficial lines such as around the eyes and mouth, products with high fluidity are injected into the dermis with fine-tipped needles. Fillings that are placed too superficially cause color change on the surface, while those that are placed too deep are lost in the tissue.

Today, dermal fillers are permanent, semi-permanent and temporary (biodegradable). Permanent fillings last for more than two years and are fillers with large particles. Products such as silicone and microspheres are examples of this group. Semi-permanent fillers are synthetic products consisting of fine particles and microspheres. They last for a year or two. These include calcium hydroxyapatite and poly-l-lactic acid. Temporary biodegradable fillings are products that last for less than a year. Among these products, the frequently used ones are collagen and hyaluronic acid.

Collagen is injected into the skin and replaces the natural collagen lost during aging. Bovine, porcine and human varieties are available, but bovine and porcine varieties may cause a hypersensitivity reaction. The most used skin fillers today are products containing hyaluronic acid. This chemical is a key component in the polysaccharide structure found naturally in the dermis. It keeps the skin moist, adds volume and acts as a cushion. Unlike collagen, it has the same structure in all living things and does not show species or tissue specificity. Stabilization of hyaluronic acid is achieved by cross-linking within the polysaccharide chain.

Whichever skin filler will be used, tests and analyzes to be carried out in advanced laboratories are extremely important to ensure that it is compatible with the person's body values.

given to businesses by our organization Among numerous testing, measurement, analysis and evaluation studies, there are also chemical analysis services of skin fillers.