Hyaluronic acid is a natural substance found in the fluids in the eyes and joints. It acts as a cushion and lubricant in joints and other tissues. Different forms of hyaluronic acid are used for cosmetic purposes. Hyaluronic acid may also affect the body's response to injury and help reduce swelling. People often take hyaluronic acid by mouth and apply it to the skin for urinary tract infections, acid reflux, dry eyes, wound healing, aging skin, and many other conditions, but there is no good scientific evidence to support most of these uses.
Meanwhile, hyaluronic acid can help increase skin moisture, which can provide a variety of skin benefits, such as reducing the appearance of wrinkles and speeding up wound healing.
In short, the benefits of hyaluronic acid can be listed as follows: anti-aging, moisturizing, wound healing, anti-wrinkle, increasing skin elasticity, treating eczema and treating facial redness.
Hyaluronic acid, in particular, can bind up to a thousand times its weight in water. In other words, it acts as a humectant and keeps water molecules on the surface of the skin, keeping the skin nice and moist. Hyaluronic acid keeps the skin moist by slowing down the rate of evaporation of water. In addition to being a very effective moisturizer, some studies have found that it is also very good for healing wounds.
In the cosmetics and skin care industry, few substances have received as much attention as hyaluronic acid. Preferred for its extraordinary ability to moisturize and plump the skin, hyaluronic acid has become the cornerstone of skin care formulas and topical treatments. Behind its effectiveness lies a complex laboratory testing and validation process that requires expertise.
Developing a test method for hyaluronic acid begins with understanding its properties and behavior. Because of its unique ability to absorb water, the testing process must account for potential fluctuations in moisture content. Moisture content is often a critical parameter sought in hyaluronic acid testing. Contamination or improper handling can significantly skew results. The basic steps in moisture analysis are:
Hyaluronic acid purity is confirmed by chemical analysis, usually using high-performance liquid chromatography (HPLC). This technique allows accurate measurement of hyaluronic acid content in raw materials and finished products.
Beyond purity, the performance of hyaluronic acid over time is evaluated through stability testing. Stability and performance testing of hyaluronic acid includes hydration and swelling tests. Samples are subjected to controlled conditions to observe swelling behavior over hours or days, which is critical to understanding product performance and shelf life.
Once testing and analysis are complete, a comprehensive certificate of analysis is issued. This document provides customers with assurance regarding the quality, purity and performance characteristics of the cosmetic or over-the-counter product containing hyaluronic acid.
The standard “ASTM F234-03 Standard guide for characterization and testing of hyaluronan as starting materials for use in biomedical and tissue engineering medical product applications” published by the American Society for Testing and Materials (ASTM) describes a procedure for evaluating hyaluronan for use in biomedical or pharmaceutical applications, or both, including but not limited to tissue engineering medical products.
This standard addresses the basic parameters related to the characterization and purity of hyaluronan. As with any material, some properties of hyaluronan can be altered by processing techniques, such as cross-linking and sterilization, required for the manufacture of a particular formulation or device. Therefore, the properties of manufactured forms of this polymer should be evaluated using test methods not covered in this guideline, as appropriate, to ensure safety and efficacy.
Hyaluronan (hyaluronic acid) is a polysaccharide with a disaccharide repeating unit composed of D-glucuronic acid and N-acetylD-glucosamine. Each disaccharide unit is bonded to the next. Hyaluronan is a linear polymer.
Our organization, which has been trying to support businesses from every sector with its wide range of testing, measurement, analysis and evaluation studies for years, has a strong staff that closely follows the developments in the world in the field of science and technology and constantly improves itself. In this context, hyaluronic acid analysis services are also provided to businesses.
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