N-nitrosoanabazine is a natural product found in nicotine in tobacco with available data.
-analizi.jpg "NAB (N-Nitrosoanabazine) Analysis")
N-nitrosoanabazine (NAB) is a minor tobacco alkaloid derived from a tertiary amine known as anabazine. Alkaloids are chemical compounds of an amine structure that are naturally produced by plants. N-nitrosoanabazine belongs to a group of nitrosamines called nitrosamines specific to tobacco. It is thought that minor alkaloids like N-nitrosoanabazine arise from bacterial action or oxidation during tobacco processing.
Nitrosamines are chemically stable compounds under physiological conditions, but are the main causative agents of lung, pancreatic, esophageal and oral cavity cancers.
Activation of tobacco-specific nitrosamines via α-hydroxylation causes them to bind to DNA and other cellular macromolecules. This results in biological actions such as carcinogenicity, mutagenicity, embryopathy and other teratogenic actions. The N-nitrosoanabazine compound is only found in people who smoke or are exposed to tobacco smoke.
N-nitrosoanabazines belong to the class of organic compounds known as alkaloids and derivatives. These are naturally occurring chemical compounds that mostly contain basic nitrogen atoms. This group also includes some related compounds with neutral or even weakly acidic properties. In addition, some synthetic compounds with similar structure are attributed to alkaloids. In addition to carbon, hydrogen, and nitrogen, alkaloids may contain other elements such as oxygen, sulfur and, more rarely, chlorine, bromine, and phosphorus.
Tobacco products contain carcinogenic tobacco-specific nitrosamines, which play an important role in tobacco use-related human cancers. Tobacco-specific nitrosamines, n-nitrosoanabazine and n-nitrosoanatabine, are abundant in all tobacco products, cigarette smoke, and even atmospheric particulate matter. The toxication pathways of metabolism of both compounds are important triggers for their carcinogenicity. However, the molecular details of the poisoning mechanisms are not well understood until now. This precludes a comprehensive risk assessment of the exposures of these two compounds. Since the carcinogenic effect of cigarette smoke cannot be explained by the known carcinogenic content, other carcinogenic components continue to be investigated. Studies conducted today have proven the highly carcinogenic effect of certain nitrosamines.
Among the numerous tests, measurements, analyses, and evaluations our organization provides for businesses in various sectors, we also offer NAB (n-nitrosoanabazine) analysis services with our trained and expert staff and advanced technological equipment.
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