Classified in the third group of carcinogens, n-nitrosoanatabine (NAT) belongs to the class of tobacco-specific nitrosamines, such as n-nitrosoanabazine (NAB). Tobacco-specific nitrosamines are carcinogenic compounds formed by burning, curing and fermentation of tobacco leaves. Their levels in tobacco can vary and can be significantly related to the amount of nitrate in tobacco. N-nitrosoanabatin is produced together with n-nitrosonornicotine in tobacco. This compound can be detected in e-cigarette cartridges, mainstream tobacco smoke, snuff, and similar products.
-analizi.jpg "NAT (N-Nitrosoanabatin) Analysis")
Nitrosamines are chemically stable compounds under physiological conditions, but are the main causative agents of lung, pancreatic, esophageal and oral cavity cancers. Activation of tobacco-specific nitrosamines via α-hydroxylation causes them to bind to DNA and other cellular macromolecules. This results in biological actions such as carcinogenicity, mutagenicity, embryopathy and other teratogenic actions.
Tobacco products contain carcinogenic tobacco-specific nitrosamines, which play an important role in tobacco use-related human cancers. The tobacco-specific nitrosamines, n-nitrosoanatabine and n-nitrosoanabazine, are abundant in all tobacco products, cigarette smoke, and even atmospheric particulate matter. The toxication pathways of metabolism of both compounds are important triggers for their carcinogenicity.
The link between tobacco abuse and cancer is well established. However, emerging data indicate that toxins in tobacco smoke cause cellular damage due to the increased toxic/metabolic effects of metabolites, disruption of intracellular signaling mechanisms, and the formation of DNA, protein, and lipid adducts that impair function and promote oxidative stress and inflammation. These largely non-carcinogenic effects of smoking are produced by tobacco-specific nitrosamines and their metabolites. These factors explain the increased rates of neurodegeneration and insulin resistance diseases among smokers.
Smoking and smokeless tobacco consumption pose health risks due to concomitant exposure to nicotine and toxic alkaloid metabolites of tobacco-specific nitrosamines. Tobacco-specific nitrosamines are highly carcinogenic and increase risks with DNA and hemoglobin. Tobacco-specific nitrosamines are detected in saliva and their metabolites are detected in urine.
Our organization also provides NAT (n-nitrosoanabatin) analysis services with its trained and expert staff and advanced technological equipment, among the numerous test, measurement, analysis and evaluation studies it provides for businesses in various sectors.
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