Subacute toxicity studies are performed to evaluate the potential side effects of a new drug following a treatment period of 2-4 weeks. Subacute toxicity studies are conducted as range-finding studies to select dosage levels to be used in subsequent subchronic and chronic toxicity studies. Subacute means between acute and chronic. Subacute toxicity studies are also being done to support initial clinical trials where treatment duration is up to 4 weeks. These studies are designed to evaluate the progression and regression of drug-induced lesions, but are often insufficiently timed to describe any secondary effects that occur during long-term clinical use or testing for chronic toxicity and carcinogenicity.
Acute toxicity studies in animals are generally required for any pharmaceutical for human use. Information from these studies is useful in dose selection for repeat-dose studies, pre-identifying target organs of toxicity, and sometimes detecting delayed toxicity. Acute toxicity studies also assist in the selection of starting doses for human studies and provide information on acute overdose in humans.
Acute toxicity is the toxicity of a drug when given in one or more doses over a period not exceeding 24 hours.
All kinds of drugs, cosmetics, cleaning agents, food additives, pesticides and all kinds of chemicals used in industry that people may be exposed to must be tested for their toxic potential before being offered to consumers. In these tests, the toxicity characteristics of the substances in question are tested by considering the usage patterns, exposure routes and exposure times.
In these tests performed in advanced laboratories, possible toxic effects are examined in test animals under in vivo conditions or in cell cultures in vitro conditions. However, it is not always possible to adapt the results obtained to humans due to various factors.
Toxicity tests are generally classified according to the length of the test period as follows: acute toxicity tests, subacute toxicity tests, chronic toxicity tests, subchronic toxicity tests, and specific toxicity tests.
Our organization also provides subacute toxicity testing services with its trained and expert staff and advanced technological equipment, among the numerous test, measurement, analysis and evaluation studies it provides for businesses in various sectors.
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