N-Nitrosodiethylamine (NDEA) is a synthetic photosensitive, volatile and clear yellow oil, soluble in water, lipids and other organic solvents. It is used as gasoline and lubricant additive, antioxidant and stabilizer for industrial materials. N-Nitrosodiethylamine (NDEA) emits toxic nitrogen oxide fumes when heated to decomposition. This compound probably affects DNA integrity through alkylation and is used in experimental research to induce liver tumorigenesis. It is generally considered to be carcinogenic to humans.
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The boiling point of this organic compound is between 175-177 degrees and is used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics.
N-Nitrosodiethylamine (NDEA) is a nitrosamine and has roles as a mutagen, hepatotoxic agent and carcinogen. In the pharmaceutical industry, nitrosamines are detected as undesirable by-products of production due to various raw materials. N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA) have been identified as possibly carcinogenic compounds for humans according to the International Agency for Research on Cancer classification. These compounds are among the simplest nitrosamines. N-Nitrosamines in cosmetics and their precursors are seen as carcinogenic agents in humans.
The discovery of nitrosamines in some pharmaceutical and cosmetic products has prompted international regulatory agencies to conduct a detailed analysis of these impurities in the affected active ingredients and drug products. When nitrosamine impurities are found in some drug products and these impurities rise to unacceptable levels, these products are recalled.
Nitrosamines are a well-known group of highly potent, mutagenic impurities formed by the reaction of secondary amines with nitrite under acidic conditions. Nitrosamines have been investigated for many years because they are found in foods, cosmetics, tobacco products, industrial solvents, and alcoholic beverages. The primary toxicity concern with nitrosamines, which are found in the environment as impurities in the human diet, tobacco products, cosmetics, and pharmaceuticals, is that these structures are genotoxic chemical carcinogens.
No epidemiological studies have been conducted to evaluate the relationship between NDEA exposure and cancer. However, several case-control studies and ecological studies exist.
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