A European standard, EN 16274, defines a test method for the identification and detection of 24 suspected volatile allergens from ready-to-inject cosmetics and raw materials used in cosmetic products. This test method is compatible with gas chromatography analysis. This analysis uses gas chromatography - mass spectrometry (GC-MS) method after sample preparation. 24 suspected allergens are restricted within the scope of the cosmetics directive 2003/15/EC in force in the European Union countries.
The method described in this standard includes a comprehensive analysis of 24 volatile suspected allergens, for example, by gas chromatography coupled with mass spectrometry after dilution in an inert solvent. In this analysis, two assays are performed for chromatographic separation of 24 suspected allergens using two gas chromatography capillary columns of different polarities. Suspected allergen identification is obtained using gas chromatography - mass spectrometry in scanning mode, whenever possible. Quantification is performed by single ion tracking. The final result depends on the agreement of the different ion ratios obtained for both injections according to the specific requirements. Unless otherwise stated, only reagents considered analytical grade are used.
These analyzes allow to determine the type and amount of volatile compounds suspected to be allergens in fragrance compositions and raw materials used in cosmetic products. These analyzes are performed on gas chromatography - mass spectrometry ready-to-inject matrix samples that are compatible with gas chromatography. A gas chromatograph device equipped with a flame ionization detector is used in these analyzes. This instrument is used only to determine the purity of reference samples intended for calibration and, if necessary, to determine standards or quantify highly concentrated analytes prior to quantitative analysis.
Among the numerous test, measurement, analysis and evaluation studies that our organization provides for businesses in various sectors, with its trained and expert staff and advanced technological equipment, within the scope of EN 16274 standard, GC analysis services of ready-to-inject sample for the determination of the amount of suspected odor allergens in consumer products. gives.
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