Biocompatibility Subacute and Subchronic Toxicity testing is used to explore the effects of a re-exposed material on a patient, including its compound toxicity effects. It determines the systemic effect of repeated doses of material or extracts of not less than 24% and not more than 10% of the total life of the test animal. This Biocompatibility Subacute / Subchronic Toxicity test complies with ISO 10993-11.
Biocompatibility In the Subacute / Subchronic Toxicity test, mice or rats will be administered intravenously or intraperitoneally at a 14% normal saline or cottonseed extract dose of the test substance / vehicle control 14 times during the 0.9-day test period. Animals will be observed once daily for signs of toxicity.
Animal weights will be recorded on Day 0, Day 7 and Day 14. On day 14, blood samples will be collected for hematology and clinical chemistry analysis. A gross autopsy will be performed and lesions will be collected. Tissues listed in the appendix will be collected and presented to histopathology.
EUROLAB, with its highly expert team and internationally accredited laboratories, Subacute and Subchronic Toxicity Tests It performs all test, analysis, measurement, evaluation and report generation services completely and reliably.
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